Protein Details: Aquaporin PIP2-2
Protein ID
ICDB_Pro_0530
Protein Name
Aquaporin PIP2-2
Gene Name
PIP2-2; PIP2B; At2g37170; T2N18.7
Organism
Arabidopsis thaliana (Mouse-ear cress)
Length
285 amino acids
AlphaFoldDB
AF-P43287-F1-model_v4.pdb
Function
Water channel required to facilitate the transport of water across cell membrane. Plays an predominant role in root water uptake process in conditions of reduced transpiration; and in osmotic fluid transport. Its function is impaired by Hg(2+). Inhibited by cytosolic acidosis which occurs during anoxia in roots.
Sequence
MAKDVEGPEGFQTRDYEDPPPTPFFDADELTKWSLYRAVIAEFVATLLFLYITVLTVIGYKIQSDTKAGGVDCGGVGILGIAWAFGGMIFILVYCTAGISGGHINPAVTFGLFLARKVSLIRAVLYMVAQCLGAICGVGFVKAFQSSYYDRYGGGANSLADGYNTGTGLAAEIIGTFVLVYTVFSATDPKRNARDSHVPVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNKSKPWDDHWIFWVGPFIGAAIAAFYHQFVLRASGSKSLGSFRSAANV
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Predominantly expressed in the root; with a strong expression in the cortex; endodermis; and stele.
DOI ID
10.1046/j.1365-313x.1994.6020187.x; 10.1038/45471; 10.1111/tpj.13415; 10.1105/tpc.008888; 10.1186/gb-2001-3-1-research0001; 10.1038/nature01853; 10.1042/bj20060569
RefSeq
NP_181254.1